In "The Story on Page One", Peter Griffin is a Ghostbuster in a flashback and interrupts the famous potter wheel scene in the film Ghost and sucks up Swayze. "Baby Not On Board" also reenacts the potters wheel scene while Peter is getting a massage.
He also appears in "Padre de Familia" with a more realistic ending to the film Dirty Dancing.
"Brian's Got a Brand New Bag" is dedicated to him. The first act heavily references his films Road House, which airs on the Griffin television at the start of the episode, as well as Ghost.
Peter falls asleep after watching a Patrick Swayze Christmas movie and dreams he is visited by Patrick's ghost in "Don't Be a Dickens At Christmas". Here, Patrick is voiced by Swayze's younger brother, Don Swayze.