This article is about the ultimate endgame of senescence. You may be looking for the character of the same name.

Deaths are the permanent and irreversible bodily cessations of humans, animals, and other organisms, that were once living, prior to the phenomenons in question. Deaths are inevitable for all living beings, no matter how long their lives may be, (except, maybe the so-called "Immortal Jellyfish", but don't get me started on that) but the causes of death, vary based on the deceased figure. Death is generally caused by aging, which is considered to be the "natural causes" for death, although many lives are curtailed by other phenomena, such as murder, disease, suicide, predation, malnutrition, starvation, dehydration, asphyxiation, and non-vaccination.

Death occurs among many characters of Family Guy, and more often than not, it's presented as a one-time joke, and the deceased characters come back to life, almost immediately afterwards. However, there have been several occasions, where characters have been killed off for real, via being written off of the show. Characters are killed off, either due to outliving their usefulness, needing to be written off the show for a future story arc to be made possible, their voice actors dying in real life, or from the writers taking poor fan-reception into consideration, and getting rid of the lesser-beloved characters. Most deaths in the show are proceeded by the show's character, Death entering the scene and reaping their corpses.

Major/Recurring Character Deaths

Character Episode Cause of Death Age Replacement Notes
Mr. Weed "Mr. Saturday Knight" Choking Unknown Angela N/A
Patty Tanniger "Hell Comes to Quahog" Crushing Unknown N/A N/A
Vern and Johnny "Saving Private Brian" Murder Unknown N/A N/A
Francis Griffin "Peter's Two Dads" Crushing Unknown N/A N/A
Loretta Brown "Gone With the Wind" Falling out of the bathtub Unknown Donna Tubbs-Brown This was in an episode of The Cleveland Show. Not Family Guy.
Muriel Goldman "And Then There Were Fewer" Murder Unknown N/A N/A
Diane Simmons "And Then There Were Fewer" Murder Unknown Joyce Kinney N/A
Horace "Save the Clam" Brain Damage via Baseball 40's-50's Jerome Cool J N/A
Bertram "The Big Bang Theory" Murder 0 N/A N/A
Thelma Griffin "Mom's the Word" Natural Causes Unknown N/A N/A
Brian Griffin "Life of Brian" Vehicular Manslaughter 56 Vinny Griffin He came back to life in "Christmas Guy".
Frank Sinatra Jr. N/A Natural Causes 72 N/A Done because his voice actor died.
Lance Prueher "Brian Come Home for Christmas" Suicide 40's-50's N/A Ironically, he worked at a Suicide Hotline.
Jess Griffin "Dead Dog Walking" Cancer 40's N/A This was actually her second time dying, (Married ... Without Cancer).
Angela "Pawtucket Pete" Swimming less than 20 minutes after eating Unknown Bert & Sheila Done because her voice actor died.
Mayor Adam West "Adam West High" Natural Causes 88 TBA Done because his voice actor died.

Minor/Background Character Deaths

Character Episode Cause of Death Age Replacement Notes
Sam Gullet The D in apartment 23 Throat slit by Chris. 13-17 N/A N/A
Two unnamed boys The D in apartment 23 Stabbed by Chris 13-17 N/A N/A
Adam Frias The D in apartmet 23 Unknown 13-17 N/A N/A
Ryan Mitchum The D in apartment 23 Unknown 13-17 N/A N/A
Katina Langley The D in apartment 23 Eye stabbed with high heel by Meg. 13-17 N/A N/A
Kelly Risentill The D in apartment 23 Stabbed by Chris 13-17 N/A Offscreen
Steven Blanc The D in apartment 23 Crushed by a flying lunch cart 13-17 N/A It is very likely that Chris killed him.
Brandy Luther The D in apartment 23 Stabbed by Meg. 13-17 N/A N/A
Terrence Joeseph The D in apartment 23 Stabbed in the face twice by Meg. 13-17 N/A He was unable to see at the time
Darren Grant The D in apartment 23 Head twisted by Chris. 13-17 N/A N/A
Clemont Douglas The D in apartment 23 Stabbed by Chris 13-17 N/A N/A
Bryan Lee The D in apartment 23 Stabbed by Chris 13-17 N/A This episode was his only known appearence
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