Brian and Stewie's Relationship is the relationship between Brian Griffin and Stewie Griffin.
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Brian and Stewie are one of the show's most iconic and recognizable dynamic duo, famous for their brilliant chemistry, contrasting personalities, on & off "frenemy" shtick, constant switching of "straight man" and "comic" statuses, and overall, their relatable behavior. Brian and Stewie are the best of friends, as Brian is seemingly the only person in the family who can actually understand Stewie. Sometimes, they fight and you never know who's going to win. Brian and Stewie go through bonding experiences, when it comes to their time travel journeys and their occasional "Road to" episode adventures.