She portrayed the American version of Mother Maggie for Jolly Farm Revue in "Go, Stewie, Go!".
She appeared as herself in "April in Quahog", and voiced a "Hot Blonde" in It's A Trap!.
When Stewie becomes a celebrity in "The Peanut Butter Kid", Peter feels he understands what it is like to be Anne Hathaway's parents. A cutaway shows her arriving in her car, while her parents groan at her arrival.