In "Road to the North Pole", Quagmire takes her to sit on Santa Claus's lap at the mall so she can tell him what she wants for Christmas. Quagmire's enemy, Brian Griffin, tries to make amends with Glenn by being nice to her. However, he mistakes her for a boy, and scares her into thinking that she's dying.
When Brian and Stewie get home, Lois gets a call from Glenn saying that Abby's cancer has returned and that she is in the Intensive Care unit at the hospital.
Abby is voiced by Karley Scott Collins.